(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Base Information

Chemical Name:(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
CAS No.:220453-06-5
Molecular Formula:C₁₄H₁₄F₃NO₂
Molecular Weight:285.266
Hs Code.:

Synonyms:(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Chemical Property:

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Technology Process of (3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

There total 2 articles about (3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 184157-09-3
6,6,6-trifluoro-5-oxohexanoic acid

: 220453-06-5
(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.1021/ja983389n

Reference yield:

: (3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione

: 220453-06-5
(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: With water; bromoacetic acid methyl ester;
DOI:10.1016/j.bmcl.2003.12.101

Reference yield:

: 220453-06-5
(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 220453-26-9
(3S,5S,8aS)-5-Allyl-3-phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KHMDS / 1.) -78 deg C

2: 76 percent / CuI

3: 83 percent / H₂ / PtO₂ / toluene / 2327.17 Torr

4: 55 percent / 2-O₂N-C₆H₄SeCN, Bu₃P, H₂O₂

With copper(l) iodide; ortho-nitrophenyl selenocyanate; tributylphosphine; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; platinum(IV) oxide; In toluene;
DOI:10.1021/ja983389n