methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

Base Information

Chemical Name:methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate
CAS No.:934286-10-9
Molecular Formula:C₂₇H₂₃Cl₃N₄O₃
Molecular Weight:557.864
Hs Code.:

Synonyms:methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Property of methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

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Technology Process of methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

There total 10 articles about methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 934286-08-5
methyl 4-[2-(5-chloro-1-(3,4-dichlorobenzyl)-2-{2-[(methylsulfonyl)oxy]ethyl}-1H-indol-3-yl)ethoxy]benzoate

: 934286-10-9
methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: With sodium azide; In dimethyl sulfoxide;
DOI:10.1021/jm061131z

Reference yield:

: 124064-21-7
4-(2-oxo-ethoxy)-benzoic acid methyl ester

: 934286-10-9
methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 0.216 g / Et₃SiH; TFA / CH₂Cl₂

2: 0.129 g / TBAF / tetrahydrofuran

3: 0.149 g / Et₃N / tetrahydrofuran / 72 h

4: 88 percent / NaN₃ / dimethylsulfoxide

With triethylsilane; sodium azide; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm061131z

Reference yield:

: 1028258-19-6
C₃₃H₃₂Cl₃NOSi

: 934286-10-9
methyl 4-{2-[2-(2-azidoethyl)-5-chloro-1-(3,4-dichlorobenzyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 0.216 g / Et₃SiH; TFA / CH₂Cl₂

2: 0.129 g / TBAF / tetrahydrofuran

3: 0.149 g / Et₃N / tetrahydrofuran / 72 h

4: 88 percent / NaN₃ / dimethylsulfoxide

With triethylsilane; sodium azide; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm061131z