N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

Base Information

Chemical Name:N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide
CAS No.:1380835-94-8
Molecular Formula:C₁₂H₁₃Cl₂F₃N₂O
Molecular Weight:329.149
Hs Code.:

Synonyms:N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

Chemical Property:

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Technology Process of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

There total 5 articles about N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 889940-13-0
3,3,3-trifluoro-2,2-dimethylpropanoic acid

: 1360623-97-7
3-amino-2,4-dichloro-benzylamine

: 1380835-94-8
N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

Guidance literature:: With 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 45 ℃;

Reference yield:

: 1360623-95-5
3-amino-2,4-dichloro-benzamide

: 1380835-94-8
N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 11 h / 20 °C / Reflux

2: triethylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 45 °C

With lithium aluminium tetrahydride; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran;

Reference yield:

: 17700-55-9
N-(2,6-Dichloro-3-methylphenyl)acetamide

: 1380835-94-8
N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; potassium permanganate / water / 6 h / 70 °C / Reflux

2.1: hydrogenchloride; water / acetic acid / 24 h / Reflux

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / tetrahydrofuran / 4 h / 20 °C

3.2: 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 11 h / 20 °C / Reflux

5.1: triethylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 45 °C

With pyridine; hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; water; triethylamine; In tetrahydrofuran; water; acetic acid;