2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine

Base Information

• Chemical Name: 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine
• CAS No.: 171515-13-2
• Molecular Formula: C₁₇H₇ClF₆N₂O₄
• Molecular Weight: 452.697

Synonyms:2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine

Chemical Property of 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine

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Technology Process of 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine

There total 2 articles about 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

2-Carboxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine (171515-07-4) + trifluoroacetic anhydride (407-25-0) → 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine (171515-13-2)

Guidance literature:

at 40 ℃; for 2h;

DOI:10.1016/0022-1139(95)03239-A

Reference yield:

2-carbethoxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine (160436-51-1) → 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine (171515-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87.3 percent / 10percent KOH / 2 h / 100 °C

2: 82.6 percent / 2 h / 40 °C

With potassium hydroxide;

DOI:10.1016/0022-1139(95)03239-A

Reference yield: 92.6%

2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine (171515-13-2) → N-[6-(4-Chloro-phenyl)-4-trifluoromethyl-furo[2,3-b]pyridin-3-yl]-2,2,2-trifluoro-acetamide + 2,9-Bis(trifluoromethyl)-7-p-chlorophenyl-4-oxo-4H-pyrido<3',2':4,5>furo<3,2-d>-1,3-oxazine (171515-19-8)

Guidance literature:

With acetic anhydride; at 110 ℃; for 2h;

DOI:10.1016/0022-1139(95)03239-A

upstream raw materials:

2-Carboxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro<2,3-b>pyridine

trifluoroacetic anhydride

2-carbethoxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine

Downstream raw materials:

2,9-Bis(trifluoromethyl)-7-p-chlorophenyl-4-oxo-4H-pyrido<3',2':4,5>furo<3,2-d>-1,3-oxazine

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