(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Base Information

Chemical Name:(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1059700-13-8
Molecular Formula:C₃₉H₅₀N₄O₆S
Molecular Weight:702.915
Hs Code.:

(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 6 articles about (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81363-76-0
propane-2-sulfonamide

: 1059701-66-4
(1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

: 1059700-13-8
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1033906-79-4
5-tert-butyl 1a-ethyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

: 1059700-13-8
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3.33 h / 0 - 20 °C

1.2: 0 °C / pH <= 4

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C

3.1: potassium carbonate / tetrahydrofuran / 20 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.2: pH > 8

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; sodium hydroxide; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1059700-79-6
(4bR,5aS)-9-(tert-butoxycarbonyl)-12-cyclohexyl-3-methoxy-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino-[1,2-a]indole-5a-carboxylic acid

: 1059700-13-8
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C

2.1: potassium carbonate / tetrahydrofuran / 20 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.2: pH > 8

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;