(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

Base Information

Chemical Name:(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one
CAS No.:1535200-70-4
Molecular Formula:C₂₈H₃₅N₃O₂
Molecular Weight:445.605
Hs Code.:

Synonyms:(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

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Chemical Property of (S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

Chemical Property:

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Technology Process of (S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

There total 6 articles about (S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₃N₃O₄

: 1535200-70-4
(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1016/j.bmcl.2013.12.021

Reference yield:

: 22837-81-6
3-napthalen-1-yl-acrylic acid methyl ester

: 1535200-70-4
(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 775.74 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

3: triethylamine / dichloromethane / 1 h / 0 °C

4: tetrahydrofuran / 16 h / 70 °C

5: N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 3 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.12.021

Reference yield:

: 36060-99-8
3-(naphthalen-1-yl)propionic acid methyl ester

: 1535200-70-4
(S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-(3-(naphthalen-1-yl)propyl)piperazin-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

3: tetrahydrofuran / 16 h / 70 °C

4: N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 3 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h

With lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2013.12.021