1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

Base Information

Chemical Name:1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine
CAS No.:1439396-71-0
Molecular Formula:C₂₃H₂₂N₄O
Molecular Weight:370.454
Hs Code.:

Synonyms:1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

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Chemical Property of 1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

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Technology Process of 1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

There total 4 articles about 1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1439396-73-2
{1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutyl}-carbamic acid methyl ester

: 1439396-71-0
1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 120 ℃; Inert atmosphere;

Reference yield:

: 536-74-3
phenylacetylene

: 1439396-71-0
1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 100 °C / Inert atmosphere

2: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

4: lithium hydroxide; water / 1,4-dioxane / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; water; caesium carbonate; triethylamine; lithium hydroxide; XPhos; In 1,4-dioxane; methanol;

Reference yield:

: 1439396-27-6
5-bromo-2-chloro-4-(phenylethynyl)pyrimidine

: 1439396-71-0
1-[4-(2-methoxy-6-phenyl-pyrrolo[3,2-d]pyrimidin-5-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

2: methanol / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

3: lithium hydroxide; water / 1,4-dioxane / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; caesium carbonate; lithium hydroxide; XPhos; In 1,4-dioxane; methanol;