2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

Base Information

Chemical Name:2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol
CAS No.:195621-22-8
Molecular Formula:C₂₁H₂₂ClN₃O
Molecular Weight:367.878
Hs Code.:

Synonyms:2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

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Chemical Property of 2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

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Technology Process of 2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

There total 9 articles about 2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.7%

: 5862-32-8
2,6-bis(chloromethyl)-4-methylphenol

: 1539-42-0
bis[(2-pyridyl)methyl]amine

: 195621-22-8
2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

Guidance literature:: In methanol; for 20h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ja309782m

Reference yield:

: 65448-72-8
2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde

: 195621-22-8
2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h

2: Et₃N / tetrahydrofuran / Ambient temperature

3: 100 percent / NaBH₄ / methanol / 1.) room temperature, 15 min, 2.) reflux, 30 min

4: 100 percent / SOCl₂ / 3 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja970345q

Reference yield:

: 192819-69-5
3-[(bis-(pyridin-2-yl-methyl)amino)-methyl]-2-hydroxy-5-methyl-benzaldehyde

: 195621-22-8
2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH₄ / methanol / 1.) room temperature, 15 min, 2.) reflux, 30 min

2: 100 percent / SOCl₂ / 3 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In methanol;
DOI:10.1021/ja970345q