[13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester

Base Information

• Chemical Name: [13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester
• CAS No.: 357341-99-2
• Molecular Formula: C₃₂H₃₅N₃O₅
• Molecular Weight: 543.625
• Mol file: 357341-99-2.mol

Synonyms:[13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester

Chemical Property of [13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester

There total 5 articles about [13C₂]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

[1-13C]-N-benzyloxycarbonyl-L-isoleucine (357341-97-0) + [1-13C]-L-tryptophan benzyl ester (357341-98-1) → [13C2]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester (357341-99-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(01)00449-5

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → [13C2]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester (357341-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / aq. NaOH / 2 h / 20 °C

2: 86 percent / Et₃N; BOP / acetonitrile / 2 h / 20 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4020(01)00449-5

Reference yield:

[1-13C1]-L-tryptophan (81201-92-5) → [13C2]-N-benzyloxycarbonyl-L-isoleucil-L-tryptophan benzyl ester (357341-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / p-TsOH*H₂O / toluene / 12 h / Heating

2: 86 percent / Et₃N; BOP / acetonitrile / 2 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine; In toluene; acetonitrile;

DOI:10.1016/S0040-4020(01)00449-5

upstream raw materials:

[1-13C]-N-benzyloxycarbonyl-L-isoleucine

[1-13C]-L-tryptophan benzyl ester

benzyl chloroformate

[1-¹³C₁]-L-tryptophan