7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium

Base Information

• Chemical Name: 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium
• CAS No.: 78498-73-4
• Molecular Formula: C₁₆H₁₂ClN₂O*Li
• Molecular Weight: 290.678
• Mol file: 78498-73-4.mol

Synonyms:7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium

Chemical Property of 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium

There total 1 articles about 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazepam (439-14-5) → 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium (78498-73-4)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -60 ℃;

DOI:10.1021/jo00333a002

Reference yield: 77.0%

[RuCl2(p-cymene)]2 (658044-18-9,128706-72-9,52462-29-0) + 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium (78498-73-4) → [Ru(II)Cl(η6-p-methylisopropylbenzene)(diazepam)] (478921-33-4)

Guidance literature:

In tetrahydrofuran; under N2, stirring for 1.5 d at -78°C; solvent was evapd., residue was extd. with CH2Cl2, filtered (silica gel), concd., layered with hexane, stored for 2 d at -20°C; elem. anal.;

DOI:10.1021/om0205288

Reference yield: 75.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium (78498-73-4) → 7-Chloro-3-(1-hydroxy-cyclohexyl)-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (78498-82-5)

Guidance literature:

In tetrahydrofuran; for 0.0333333h;

DOI:10.1021/jo00333a002

upstream raw materials:

diazepam

Downstream raw materials:

3-Benzoyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

7-Chloro-3-isopropyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

7-Chloro-3-(diphenylhydroxymethyl)-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

7-Chloro-3-cyclohexylidene-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one