N-[(Benzyloxy)carbonyl]-L-alanine

Base Information

Chemical Name:N-[(Benzyloxy)carbonyl]-L-alanine
CAS No.:1142-20-7
Molecular Formula:C11H13NO4
Molecular Weight:223.229
Hs Code.:DERIVATION
European Community (EC) Number:214-532-8
DSSTox Substance ID:DTXSID40150674
Nikkaji Number:J80.198D
Wikidata:Q27095370
Metabolomics Workbench ID:149070
ChEMBL ID:CHEMBL1231234
Mol file:1142-20-7.mol

Synonyms:Cbz-Ala;Cbz-alanine;N-(carbobenzoxy)alanine;N-benzoxycarbonyl-alanine;N-benzyloxycarbonylalanine;N-carbobenzyloxyalanine

Suppliers and Price of N-[(Benzyloxy)carbonyl]-L-alanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Z-L-Alanine
100g
$ 333.00

TRC
N-Benzyloxycarbonyl-L-alanine
25 g
$ 65.00

TCI Chemical
N-Carbobenzoxy-L-alanine >99.0%(HPLC)(T)
10g
$ 26.00

TCI Chemical
N-Carbobenzoxy-L-alanine >99.0%(HPLC)(T)
25g
$ 51.00

SynQuest Laboratories
L-Alanine, N-Cbz protected 97%
100 g
$ 144.00

SynQuest Laboratories
L-Alanine, N-Cbz protected 97%
1 kg
$ 560.00

SynQuest Laboratories
L-Alanine, N-Cbz protected 97%
500 g
$ 304.00

Sigma-Aldrich
Z-L-Alanine 98%
100g
$ 214.00

Sigma-Aldrich
Z-L-Alanine 98%
25g
$ 72.70

Oakwood
Z-Ala-OH 99%
5g
$ 10.00

Total 163 raw suppliers

Chemical Property of N-[(Benzyloxy)carbonyl]-L-alanine

Chemical Property:

Appearance/Colour:white powder
Vapor Pressure:7.05E-08mmHg at 25°C
Melting Point:82-84 °C
Refractive Index:-14.5 ° (C=2, AcOH)
Boiling Point:422.1 °C at 760 mmHg
PKA:4.00±0.10(Predicted)
Flash Point:209.1 °C
PSA：75.63000
Density:1.246 g/cm³
LogP:1.77680
Storage Temp.:0-6°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:223.08445790
Heavy Atom Count:16
Complexity:248

Purity/Quality:

99% ^*data from raw suppliers

Z-L-Alanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)O)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:C[C@@H](C(=O)O)NC(=O)OCC1=CC=CC=C1
Uses N-Benzyloxycarbonyl-L-alanine is an intermediate in the synthesis of Perindopril (P287500), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

Technology Process of N-[(Benzyloxy)carbonyl]-L-alanine

There total 108 articles about N-[(Benzyloxy)carbonyl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: 501-53-1,94274-21-2
benzyl chloroformate

: 1142-20-7
N-Cbz-Ala

Guidance literature:: With sodium hydroxide; In water; at 0 - 20 ℃;
DOI:10.1128/AAC.01152-16

Reference yield: 100.0%

: N-benzyloxycarbonyl-L-alanate de desyle

: 1142-20-7
N-Cbz-Ala

Guidance literature:: With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid; In water; acetonitrile; at 20 ℃; for 1h; Irradiation;
DOI:10.1021/acscatal.7b02117