(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

Base Information

Chemical Name:(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate
CAS No.:1262523-48-7
Molecular Formula:C₂₄H₃₈N₂O₉
Molecular Weight:498.574
Hs Code.:

Synonyms:(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

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Chemical Property of (2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

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Technology Process of (2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

There total 9 articles about (2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1262523-46-5
(2S)-tert-butyl-2-(tert-butoxycarbonylamino)-4-(2-chloroacetoxy)-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

: 1262523-48-7
(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

Guidance literature:: With sodium hydrogencarbonate; thiourea; In tetrahydrofuran; ethanol; at 50 ℃; for 1.5h;

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 1262523-48-7
(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 2585.81 Torr

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / -10 - -5 °C

3.2: 4 h / 20 °C / Cooling with ice

3.3: pH 2 - 3 / Cooling with ice

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: dichloromethane / 24 h / 20 °C

6.1: thiourea; sodium hydrogencarbonate / ethanol; tetrahydrofuran / 1.5 h / 50 °C

With boron trifluoride diethyl etherate; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; thiourea; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; 5.1: Passerini Reaction;

Reference yield:

: 80963-08-2
N-tert-butoxycarbonyl-L-aspartic acid β-benzyl α-tert-butyl diester

: 1262523-48-7
(2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 2585.81 Torr

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / -10 - -5 °C

2.2: 4 h / 20 °C / Cooling with ice

2.3: pH 2 - 3 / Cooling with ice

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: dichloromethane / 24 h / 20 °C

5.1: thiourea; sodium hydrogencarbonate / ethanol; tetrahydrofuran / 1.5 h / 50 °C

With hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; thiourea; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; 4.1: Passerini Reaction;