benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Base Information

Chemical Name:benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate
CAS No.:1584648-43-0
Molecular Formula:C₃₀H₃₄FN₃O₄Si
Molecular Weight:547.702
Hs Code.:

Synonyms:benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

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Chemical Property of benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

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Technology Process of benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

There total 7 articles about benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1584648-42-9
(2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(3-fluorophenyl)methanone

: 124676-19-3
2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

: 1584648-43-0
benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; for 1.5h;

(2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(3-fluorophenyl)methanone; With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Further stages;

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 1584648-43-0
benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

1.2: 0.5 h / 0 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4.5 h / 80 °C

3.1: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

6.2: 2 h / -78 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 0 °C

7.2: 1 h / 0 - 20 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; calcium carbonate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1355966-32-3
3-(bromomethyl)-N-methoxy-N-methyl-2-nitrobenzamide

: 1584648-43-0
benzyl (9-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

2.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

4.2: 2 h / -78 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 0 °C

5.2: 1 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; water; ethyl acetate; N,N-dimethyl-formamide;