(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

Base Information

Chemical Name:(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol
CAS No.:946001-82-7
Molecular Formula:C₂₈H₄₇NO₃
Molecular Weight:445.686
Hs Code.:

Synonyms:(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

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Chemical Property of (2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

Chemical Property:

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Technology Process of (2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

There total 4 articles about (2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

: 946001-82-7
(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

: 158628-00-3
(3S)-(+)-8-methoxy-3-tridecyl-3,4-dihydroisocoumarin

: 158627-99-7
(3R)-(-)-8-methoxy-3-tridecyl-3,4-dihydroisocoumarin

Guidance literature:: With silica gel; In dichloromethane; at 0 ℃; for 30h; Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2007.04.092

Reference yield:

: 946001-52-1
(S)-4-isopropyl-2-(2-methoxy-6-methylphenyl)-4,5-dihydrooxazole

: 124-25-4,511542-15-7
myristylaldehyde

: (2R)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

: 946001-82-7
(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

Guidance literature:: (S)-4-isopropyl-2-(2-methoxy-6-methylphenyl)-4,5-dihydrooxazole; With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 1h;

myristylaldehyde; In diethyl ether; hexane; cyclohexane; at -78 - 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2007.04.092

Reference yield:

: 50463-84-8
2-methoxy-6-methylbenzoyl chloride

: 946001-82-7
(2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / CH₂Cl₂ / 0 - 20 °C

1.2: 3.80 g / methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

2.1: sec-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C

2.2: diethyl ether; hexane; cyclohexane / -78 - 20 °C

With sec.-butyllithium; triethylamine; In diethyl ether; hexane; dichloromethane; cyclohexane;
DOI:10.1016/j.tet.2007.04.092