(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

Base Information

Chemical Name:(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone
CAS No.:1241915-56-9
Molecular Formula:C₂₆H₂₀FN₅O₂
Molecular Weight:453.476
Hs Code.:

Synonyms:(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

Suppliers and Price of (7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

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Chemical Property of (7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

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Technology Process of (7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

There total 1 articles about (7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241915-54-7
7-(benzyloxy)-2-(4-fluorobenzoyl)quinazolin-4(3H)-one

: 1241915-56-9
(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide

2: DIEA; Ki / N,N-dimethyl-formamide

With Ki; DIEA; trichlorophosphate; In N,N-dimethyl-formamide;

Reference yield: 36.0%

: 1241915-56-9
(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

: 1241915-50-3
(R,S)-2-((4-fluorophenyl)(hydroxy)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-7-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In N,N-dimethyl-formamide; for 18h; under 760.051 Torr;

Reference yield:

: 1241915-56-9
(7-(benzyloxy)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone

: 1241915-58-1
(R,S)-(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)-7-(2-morpholinoethoxy)quinazolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / palladium-carbon / ethyl acetate; N,N-dimethyl-formamide

2: caesium carbonate / N,N-dimethyl-formamide

With caesium carbonate; acetic acid; palladium-carbon; In ethyl acetate; N,N-dimethyl-formamide;