1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

Base Information

Chemical Name:1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine
CAS No.:1055192-35-2
Molecular Formula:C₂₅H₃₁FN₄
Molecular Weight:406.546
Hs Code.:

Synonyms:1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

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Chemical Property of 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

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Technology Process of 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

There total 5 articles about 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1055192-88-5
3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 1055192-35-2
1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

Guidance literature:: 3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal; 1-(o-fluorophenyl)piperazine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

With sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.nucmedbio.2020.07.004

Reference yield: 82.0%

: 1055192-35-2
1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

Guidance literature:

Reference yield:

: 1055193-23-1
1-hydroxy-nonane-4,6-dione

: 1055192-35-2
1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 4 h / 20 °C

2.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 72 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.nucmedbio.2020.07.004