(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

Base Information

Chemical Name:(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one
CAS No.:1415380-17-4
Molecular Formula:C₁₅H₁₉N₃O₃
Molecular Weight:289.334
Hs Code.:

Synonyms:(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

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Chemical Property of (3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

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Technology Process of (3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

There total 4 articles about (3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1415380-11-8
(3R)-3-methyl-1-[(1S)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

: 108-24-7
acetic anhydride

: 1415380-17-4
(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

Guidance literature:: (3R)-3-methyl-1-[(1S)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one; With potassium carbonate; thiophenol; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

acetic anhydride; In acetonitrile; Inert atmosphere;
DOI:10.1021/jo302368y

Reference yield:

: 1415379-95-1
C₂₅H₃₇N₃O₇SSi

: 1415380-17-4
(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 12 h / Inert atmosphere

2.1: Jones reagent / acetone / 2 h / 0 °C / Inert atmosphere

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

4.1: thiophenol; potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With Jones reagent; potassium carbonate; benzotriazol-1-ol; thiophenol; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo302368y

Reference yield:

: C₁₈H₁₉N₃O₆S

: 1415380-17-4
(3R)-3-acetamido-3-methyl-1-[1-(1S)-(N-methylcarbamoyl)(phenyl)methyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Jones reagent / acetone / 2 h / 0 °C / Inert atmosphere

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

3.1: thiophenol; potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With Jones reagent; potassium carbonate; benzotriazol-1-ol; thiophenol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo302368y