methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

Base Information

Chemical Name:methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate
CAS No.:852535-75-2
Molecular Formula:C₂₂H₂₃N₃O₇S
Molecular Weight:473.507
Hs Code.:

Synonyms:methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

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Chemical Property of methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

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Technology Process of methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

There total 3 articles about methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 852535-71-8
methyl 4-(hydroxymethyl)-3-pyridin-3-ylisoxazole-5-carboxylate

: 2845-66-1
N-(tert-butoxycarbonyl)benzenesulfonamide

: 852535-75-2
methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1016/j.tet.2005.03.004

Reference yield:

: 852535-63-8
methyl 4-formyl-3-pyridin-3-ylisoxazole-5-carboxylate

: 852535-75-2
methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 4 h / 20 °C

2: 94 percent / triphenylphosphine; diethyl diazene-1,2-dicarboxylate / tetrahydrofuran / 2.5 h / 20 °C

With sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.03.004

Reference yield:

: 852535-57-0
methyl 4-(diethoxymethyl)-3-pyridin-3-ylisoxazole-5-carboxylate

: 852535-75-2
methyl 4-{[(tert-butoxycarbonyl)(phenylsulfonyl)amino]methyl}-3-pyridin-3-ylisoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / formic acid / 3 h / 20 °C

2: 100 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 4 h / 20 °C

3: 94 percent / triphenylphosphine; diethyl diazene-1,2-dicarboxylate / tetrahydrofuran / 2.5 h / 20 °C

With formic acid; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.03.004