C₁₅H₁₁F₃N₂O

Base Information

• Chemical Name: C₁₅H₁₁F₃N₂O
• CAS No.: 1335243-01-0
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26
• Mol file: 1335243-01-0.mol

Synonyms:C₁₅H₁₁F₃N₂O

Chemical Property of C₁₅H₁₁F₃N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁F₃N₂O

There total 3 articles about C₁₅H₁₁F₃N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-bromo-4-trifluoromethoxyaniline (175278-17-8) + indole-4-boronic acid pinacol ester (388116-27-6) → C15H11F3N2O (1335243-01-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol202361t

Reference yield:

2,6-dibromo-4-(trifluoromethoxy)aniline (88149-49-9) → C15H11F3N2O (1335243-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / diethyl ether; hexane / -78 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; sodium carbonate; In diethyl ether; hexane; water; N,N-dimethyl-formamide;

DOI:10.1021/ol202361t

Reference yield:

4-(trifluoromethoxy)aniline (461-82-5) → C15H11F3N2O (1335243-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid / 4.5 h / 20 °C / Molecular sieve

2: n-butyllithium / diethyl ether; hexane / -78 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; bromine; sodium carbonate; acetic acid; In diethyl ether; hexane; water; N,N-dimethyl-formamide;

DOI:10.1021/ol202361t

upstream raw materials:

2,6-dibromo-4-(trifluoromethoxy)aniline

4-(trifluoromethoxy)aniline

2-bromo-4-trifluoromethoxyaniline

indole-4-boronic acid pinacol ester

Downstream raw materials:

C₂₂H₁₄ClF₃N₂O