N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Base Information

Chemical Name:N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide
CAS No.:1198621-17-8
Molecular Formula:C₂₃H₂₄N₂O₆
Molecular Weight:424.453
Hs Code.:

Synonyms:N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

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Chemical Property of N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

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Technology Process of N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

There total 5 articles about N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1198621-16-7
N-(benzyloxy)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

: 1198621-17-8
N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: N-(benzyloxy)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide; With hydrogenchloride; In ethanol; at 23 ℃; for 5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1198621-14-5
methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

: 1198621-17-8
N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 23 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 0.25 h / 23 °C

2.2: 17 h / 23 °C

3.1: hydrogenchloride / ethanol / 5 h / 23 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 280762-58-5
5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde

: 1198621-17-8
N-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; potassium hydroxide / 0 - 23 °C

1.2: 4 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 23 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 0.25 h / 23 °C

3.2: 17 h / 23 °C

4.1: hydrogenchloride / ethanol / 5 h / 23 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; iodine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; potassium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;