N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine

Base Information

• Chemical Name: N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine
• CAS No.: 1392426-88-8
• Molecular Formula: C₁₉H₂₂ClN₃O₂
• Molecular Weight: 359.856

Synonyms:N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine

Chemical Property of N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine

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Technology Process of N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine

There total 3 articles about N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + N-(1,3-benzodioxol-5-ylmethyl)cyclohexanamine (227017-79-0) → N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine (1392426-88-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80 ℃; Inert atmosphere;

DOI:10.1039/c2ob00034b

Reference yield:

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) → N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine (1392426-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1.5 h / 25 °C / Molecular sieve; Inert atmosphere

1.2: 25 h / 17 °C / Molecular sieve; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 80 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1039/c2ob00034b

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-cyclohexyl-5-methyl-pyrimidin-4-amine (1392426-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1.5 h / 25 °C / Molecular sieve; Inert atmosphere

1.2: 25 h / 17 °C / Molecular sieve; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 80 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1039/c2ob00034b

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

N-(1,3-benzodioxol-5-ylmethyl)cyclohexanamine

1,3-benzodioxol-5-ylmethyl amine

cyclohexanone

Downstream raw materials:

N-(1,3-benzodioxol-5-ylmethyl)-2-cyano-N-cyclohexyl-5-methyl-pyrimidin-4-amine

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