N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

Base Information

Chemical Name:N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine
CAS No.:1114591-39-7
Molecular Formula:C₂₅H₃₃N₅O₅S
Molecular Weight:515.634
Hs Code.:

Synonyms:N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

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Chemical Property of N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

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Technology Process of N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

There total 6 articles about N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114592-50-5
methyl 2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimidine-4-carboxamido)-N,3-dimethylphenylsulfonamido)acetate

: 1114591-39-7
N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

Guidance literature:: methyl 2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimidine-4-carboxamido)-N,3-dimethylphenylsulfonamido)acetate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 5h;

With hydrogenchloride; In water;

Reference yield:

: 1114592-29-8
methyl 2-(4-(6-chloropyrimidine-4-carboxamido)-N,3-dimethylphenylsulfonamido)acetate

: 1114591-39-7
N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine / methanol / 1 h / 160 °C / microwave irradiation

2: sodium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C

With sodium hydroxide; water; diisopropylamine; In tetrahydrofuran; methanol;

Reference yield:

: 263270-52-6
6-chloropyrimidine-4-carbonyl chloride

: 1114591-39-7
N-({4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylphenyl}sulfonyl)-N-methylglycine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h

2: chlorosulfonic acid / dichloromethane / 0 - 20 °C

3: diisopropylamine / tetrahydrofuran / 18 h / 20 °C

4: diisopropylamine / methanol / 1 h / 160 °C / microwave irradiation

5: sodium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C

With chlorosulfonic acid; sodium hydroxide; water; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;