tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate
CAS No.:1621165-26-1
Molecular Formula:C₂₆H₃₀F₂N₄O₄
Molecular Weight:500.545
Hs Code.:

Synonyms:tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Suppliers and Price of tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 13 raw suppliers

Chemical Property of tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Chemical Property:

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

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Hazard Codes:

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Technology Process of tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

There total 4 articles about tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 695-34-1
2-Amino-4-methylpyridine

: 1308849-85-5
3,5-difluoro-4-formyl-N-methylbenzamide

: 1621165-19-2
(2S)-2-ethynylmorpholine-4-carboxylic acid tert-butyl ester

: 1621165-26-1
tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); copper(l) chloride; In N,N-dimethyl acetamide; toluene; at 85 ℃; for 5h; Inert atmosphere;

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1621165-26-1
tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; 2-methyltetrahydrofuran / 1.5 h / -78 - 20 °C

1.2: 18 h / -65 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 10 - 20 °C

3.2: 0 - 7 °C

4.1: copper(l) chloride; copper(II) bis(trifluoromethanesulfonate) / toluene; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; N,N-dimethyl-formamide; copper(l) chloride; In 2-methyltetrahydrofuran; hexane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 736990-88-8
3,5-difluoro-4-formylbenzoic acid

: 1621165-26-1
tert-butyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine- 3-yl)methyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 10 - 20 °C

2.2: 0 - 7 °C

3.1: copper(l) chloride; copper(II) bis(trifluoromethanesulfonate) / toluene; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere

With oxalyl dichloride; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; N,N-dimethyl-formamide; copper(l) chloride; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;