1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
• CAS No.: 70008-27-4
• Molecular Formula: C₂₁H₂₇NO₄
• Molecular Weight: 357.45

Synonyms:1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Chemical Property of 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

There total 3 articles about 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (70008-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

2: CH₂Cl₂ / 20 h / Ambient temperature

With thionyl chloride; In dichloromethane;

DOI:10.1080/00397919208021145

Reference yield:

ethyl (Z)-3-(methylamino)-2-butenoate (21759-70-6) + 1-[Chlor(4-methylphenyl)methyl]pyridinium-chlorid (107134-95-2) → 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (70008-27-4)

Guidance literature:

In dichloromethane; for 20h; Yield given; Ambient temperature;

DOI:10.1080/00397919208021145

Reference yield:

→ 1,2,6-trimethyl-4-p-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (70008-27-4)

Guidance literature:

Aus dem entspr. Pyridiniumsalz mit Na2S2O4;

DOI:10.1016/0040-4020(78)89054-1

upstream raw materials:

ethyl (Z)-3-(methylamino)-2-butenoate

1-[Chlor(4-methylphenyl)methyl]pyridinium-chlorid

4-methyl-benzaldehyde

Downstream raw materials:

3,5-Bis-ethoxycarbonyl-1,2,6-trimethyl-4-p-tolyl-pyridinium

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