(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1064203-23-1
Molecular Formula:C₂₀H₂₆N₂O₅S
Molecular Weight:406.503
Hs Code.:

Synonyms:(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about (+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1064203-21-9
(+/-)-3-ethyl-6-hydroxy-7-methoxy-2-(3-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 1064203-23-1
(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/cmdc.201300412

Reference yield:

: 1064203-14-0
(+/-)-3-ethyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

: 1064203-23-1
(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 1.5 h / 130 °C / Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 2 h / 20 °C

3: sulphamoyl chloride / N,N-dimethyl acetamide / 2 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide;
DOI:10.1002/cmdc.201300412

Reference yield:

: 1064207-24-4
1-(3-benzyloxy-4-methoxy-phenyl)butan-2-amine

: 1064203-23-1
(+/-)-3-ethyl-7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; acetic anhydride / dichloromethane / 4 h / 0 °C

2: toluene-4-sulfonic acid / toluene / 16 h / 120 °C

3: potassium hydroxide / ethanol; water / 66 h / 120 °C

4: triethylamine / ethanol / 1.5 h / 130 °C / Microwave irradiation

5: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 2 h / 20 °C

6: sulphamoyl chloride / N,N-dimethyl acetamide / 2 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; acetic anhydride; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene;
DOI:10.1002/cmdc.201300412