(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

Base Information

Chemical Name:(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid
CAS No.:1359669-13-8
Molecular Formula:C₂₉H₃₂O₆
Molecular Weight:476.569
Hs Code.:

Synonyms:(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

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Chemical Property of (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

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Technology Process of (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

There total 11 articles about (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1359669-90-1
tert-butyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetate

: 1359669-13-8
(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; In toluene; at 0 - 20 ℃; for 5.5h;
DOI:10.1021/jm2012968

Reference yield:

: 1359669-78-5
tert-butyl [5-(benzyloxy)-1-hydroxy-1,3-dihydro-2-benzofuran-1-yl]acetate

: 1359669-13-8
(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / toluene / 5.5 h / 0 - 20 °C

With triethylsilane; tributylphosphine; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; In ethanol; dichloromethane; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 1359669-80-9
tert-butyl [5-(benzyloxy)-1,3-dihydro-2-benzofuran-1-yl]acetate

: 1359669-13-8
(5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,3-dihydro-2-benzofuran-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / toluene / 5.5 h / 0 - 20 °C

With tributylphosphine; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; In ethanol; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jm2012968