4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide

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Chemical Name:4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide
CAS No.:1146974-98-2
Molecular Formula:C₂₅H₂₂F₄N₄O₂S
Molecular Weight:518.535
Hs Code.:

Synonyms:4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide

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Chemical Property of 4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide

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Technology Process of 4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide

There total 1 articles about 4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1146975-20-3
4-(4-(1-Cyanocyclobutylamino)-2-fluorophenyl)-N-methylbutanamide

: 143782-23-4
4-isothiocyanato 2-(trifluoromethyl)benzonitrile

: 1146974-98-2
4-(4-(7-(4-cyano-3-(trifluoromethyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorophenyl)-N-methylbutanamide

Guidance literature:: 4-(4-(1-Cyanocyclobutylamino)-2-fluorophenyl)-N-methylbutanamide; 4-isothiocyanato 2-(trifluoromethyl)benzonitrile; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Microwave irradiation;

With hydrogenchloride; methanol; water; In N,N-dimethyl-formamide; for 1.5h; Heating / reflux;