6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

Base Information

Chemical Name:6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester
CAS No.:120004-01-5
Molecular Formula:C₂₇H₂₂N₂O₄S₂
Molecular Weight:502.615
Hs Code.:

Synonyms:6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

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Chemical Property of 6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

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Technology Process of 6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

There total 4 articles about 6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

: 120004-25-3
6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 2-tert-butyl ester 5-phenethyl ester

: 120004-01-5
6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

Guidance literature:: With trifluoroacetic acid; at 20 ℃;
DOI:10.1248/cpb.36.4389

Reference yield:

: 170115-17-0
tert-butyl 3-oxo-3-(thien-2-yl)propanoate

: 120004-01-5
6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, acetic acid

2: S, (H₅C₂)2NH

3: 47.1 percent / 2-methyl-propan-2-ol / Heating

4: 90.3 percent / trifluoroacetic acid / 20 °C

With piperidine; acetic acid; diethylamine; trifluoroacetic acid; In tert-butyl alcohol;
DOI:10.1248/cpb.36.4389

Reference yield:

: (E)-4-Cyano-3-thiophen-2-yl-but-3-enoic acid tert-butyl ester

: 120004-01-5
6-Methyl-4-(3-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid phenethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: S, (H₅C₂)2NH

2: 47.1 percent / 2-methyl-propan-2-ol / Heating

3: 90.3 percent / trifluoroacetic acid / 20 °C

With diethylamine; trifluoroacetic acid; In tert-butyl alcohol;
DOI:10.1248/cpb.36.4389