(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

Base Information

• Chemical Name: (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt
• CAS No.: 1351070-11-5
• Molecular Formula: C₂₁H₁₉N₅O₆PS*Na
• Molecular Weight: 523.441
• Mol file: 1351070-11-5.mol

Synonyms:(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

Chemical Property of (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

There total 7 articles about (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt (1351070-06-8) → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt (1351070-11-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(S(P))-N6-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-97-0) → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt (1351070-11-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: ammonium fluoride / N,N-dimethyl-formamide / 120 h / 20 °C

3.1: N,N-dimethyl-formamide

4.1: sodium hydroxide / methanol

With ammonium fluoride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(R(P))-N6-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt (1351070-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium fluoride / N,N-dimethyl-formamide / 120 h / 20 °C

2: N,N-dimethyl-formamide

3: sodium hydroxide / methanol

With ammonium fluoride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.003

upstream raw materials:

(S_P)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate

(S(P))-N₆-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-N-benzylphosphoramidate

C₂₁H₂₀N₅O₆PS

(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt