N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

Base Information

Chemical Name:N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide
CAS No.:1449435-09-9
Molecular Formula:C₁₇H₁₉NO₄S
Molecular Weight:333.408
Hs Code.:

Synonyms:N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

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Chemical Property of N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

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Technology Process of N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

There total 3 articles about N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1449434-92-7
(R)-3-(4-chlorophenylsulfonyl)-4-(2-oxo-2-phenylethyl)oxazolidin-2-one

: 1449435-09-9
N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

Guidance literature:: With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/ja407027e

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 1449435-09-9
N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea / toluene / 0.5 h / 0 °C

1.2: 24 h / 0 °C

2.1: lithium hydroxide; dihydrogen peroxide / dichloromethane; tetrahydrofuran / 6 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja407027e

Reference yield:

: 156386-82-2
trans-γ-3-benzoylprop-2-en-1-ol

: 1449435-09-9
N-(1-hydroxy-4-oxo-4-phenylbutan-2-yl)-4-methylbenzensulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea / toluene / 0.5 h / 0 °C

1.2: 24 h / 0 °C

2.1: lithium hydroxide; dihydrogen peroxide / dichloromethane; tetrahydrofuran / 6 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja407027e