4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Base Information

Chemical Name:4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
CAS No.:881677-39-0
Molecular Formula:C₂₄H₂₀ClN₅O
Molecular Weight:429.909
Hs Code.:

Synonyms:4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

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Chemical Property of 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

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Technology Process of 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

There total 9 articles about 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 475587-24-7
N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyridinamine

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 881677-39-0
4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyridinamine; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

p-(chloromethyl)benzoyl chloride; In tetrahydrofuran; at 0 ℃; for 3.16667h; Inert atmosphere; Schlenk technique;
DOI:10.1021/op700270n

Reference yield:

: 99-99-0
1-methyl-4-nitrobenzene

: 881677-39-0
4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; iron / 1.5 h / 80 °C / Inert atmosphere; Schlenk technique

2.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 20 - 100 °C / Inert atmosphere; Schlenk technique

3.1: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique

4.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere; Schlenk technique

4.2: 3.17 h / 0 °C / Inert atmosphere; Schlenk technique

With iron(III) chloride; copper(l) iodide; bromine; iron; potassium carbonate; pyrographite; hydrazine hydrate; triethylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Ullmann Condensation;
DOI:10.1021/op700270n

Reference yield:

: 475587-23-6
N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine

: 881677-39-0
4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique

2.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere; Schlenk technique

2.2: 3.17 h / 0 °C / Inert atmosphere; Schlenk technique

With iron(III) chloride; pyrographite; hydrazine hydrate; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/op700270n