2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Base Information

Chemical Name:2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide
CAS No.:1403480-61-4
Molecular Formula:C₃₃H₄₂FN₃O₁₀S₂
Molecular Weight:723.841
Hs Code.:

2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Synonyms:2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

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Chemical Property of 2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

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Technology Process of 2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

There total 9 articles about 2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1403480-44-3
2-(but-3-en-1-yloxy)-N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-Nmethylphenylsulfonamido)-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

: 1403480-61-4
2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 18h;
DOI:10.1021/jm500994n

Reference yield:

: 1255212-77-1
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methyl-4-oxobutyl)(methyl)carbamate

: 1403480-61-4
2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 3.92 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 16 h / 20 °C

6.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

6.2: 2.75 h / 0 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h

With 2,6-dimethylpyridine; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm500994n

Reference yield:

: 1403480-28-3
N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

: 1403480-61-4
2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 2.75 h / 0 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm500994n