(6-bromo-3-methoxy-2-methylphenyl)methanol

Base Information

• Chemical Name: (6-bromo-3-methoxy-2-methylphenyl)methanol
• CAS No.: 110451-91-7
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.089
• Hs Code.: 2905190098
• Mol file: 110451-91-7.mol

Synonyms:(6-bromo-3-methoxy-2-methylphenyl)methanol

Chemical Property of (6-bromo-3-methoxy-2-methylphenyl)methanol

Chemical Property:

• Boiling Point: 320.0±37.0 °C(Predicted)
• PKA: 14.02±0.10(Predicted)
• Density: 1.446±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

(6-Bromo-3-methoxy-2-methylphenyl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (6-Bromo-3-methoxy-2-methylphenyl)methanol could be a useful compound for inhibiting plasma kallikrein.

Technology Process of (6-bromo-3-methoxy-2-methylphenyl)methanol

There total 3 articles about (6-bromo-3-methoxy-2-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 6-bromo-3-methoxy-2-methylbenzoate (55289-16-2) → (6-bromo-3-methoxy-2-methylphenyl)methanol (110451-91-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Ambient temperature;

Reference yield:

3-methoxy-2-methylbenzoic acid (55289-06-0) → (6-bromo-3-methoxy-2-methylphenyl)methanol (110451-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / water; acetic acid / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 4 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; bromine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; acetic acid;

Reference yield:

6-bromo-3-methoxy-2-methylbenzoic acid (55289-17-3) → (6-bromo-3-methoxy-2-methylphenyl)methanol (110451-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 4 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

methyl 6-bromo-3-methoxy-2-methylbenzoate

3-methoxy-2-methylbenzoic acid

6-bromo-3-methoxy-2-methylbenzoic acid

Refernces

• 1、 Sargent, Melvyn V.. "Naturally Occuring Dibenzofurans. Part 9. A Convenient Synthesis of Phthalides: The Synthesis of Methyl Di-O-methylporphyrilate". . p. 231 - 236. Retrieved 2007/10/02.