(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

Base Information

Chemical Name:(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol
CAS No.:623151-44-0
Molecular Formula:C₃₃H₅₀O₃Si₂
Molecular Weight:550.929
Hs Code.:

Synonyms:(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

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Chemical Property of (7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

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Technology Process of (7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

There total 7 articles about (7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 623151-43-9
(3E)-(7R,8R)-7-(tert-butyldimethylsilanyloxy)-1-(tert-butyldiphenylsilanyloxy)-8-methyldeca-3,9-dien-5-yne

: 623151-44-0
(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

Guidance literature:: (3E)-(7R,8R)-7-(tert-butyldimethylsilanyloxy)-1-(tert-butyldiphenylsilanyloxy)-8-methyldeca-3,9-dien-5-yne; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 3h;
DOI:10.1021/ol035900+

Reference yield:

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 623151-44-0
(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.42 h / 20 °C

1.2: 86 percent / I₂ / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 83 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / 3 h

3.1: 80 percent / MnO₂ / CH₂Cl₂ / 12 h

4.1: 4 Angstroem molecular sieves / toluene / 4 h / -78 °C

5.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 12 h

6.1: 9-BBN / tetrahydrofuran / 0 - 20 °C

6.2: 90 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O / 3 h / 0 °C

With 1H-imidazole; dmap; manganese(IV) oxide; copper(l) iodide; 9-borabicyclo[3.3.1]nonane dimer; Schwartz's reagent; 4 A molecular sieve; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Sonogashira coupling;
DOI:10.1021/ol035900+

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 623151-44-0
(7E)-(3R,4R)-4-(tert-butyldimethylsilanyloxy)-10-(tert-butyldiphenylsilanyloxy)-3-methyldec-7-en-5-yn-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / imidazole; DMAP / CH₂Cl₂; dimethylformamide

2.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.42 h / 20 °C

2.2: 86 percent / I₂ / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 83 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / 3 h

4.1: 80 percent / MnO₂ / CH₂Cl₂ / 12 h

5.1: 4 Angstroem molecular sieves / toluene / 4 h / -78 °C

6.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 12 h

7.1: 9-BBN / tetrahydrofuran / 0 - 20 °C

7.2: 90 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O / 3 h / 0 °C

With 1H-imidazole; dmap; manganese(IV) oxide; copper(l) iodide; 9-borabicyclo[3.3.1]nonane dimer; Schwartz's reagent; 4 A molecular sieve; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Sonogashira coupling;
DOI:10.1021/ol035900+