(2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

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Chemical Name:(2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol
CAS No.:757239-82-0
Molecular Formula:C₂₅H₂₆F₆O₃
Molecular Weight:488.47
Hs Code.:

Synonyms:(2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

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Chemical Property of (2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

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Technology Process of (2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

There total 1 articles about (2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 297169-59-6
(2R,3R,4R)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-carboxaldehyde

: 1730-25-2
allylmagnesium bromide

: 757239-82-0
(2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

Guidance literature:: allylmagnesium bromide; With B-chlorodiisopinocampheylborane; In diethyl ether; at -40 - 20 ℃; for 1h;

(2R,3R,4R)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-carboxaldehyde; In diethyl ether; at -78 - 20 ℃; for 3h;

With dihydrogen peroxide; sodium acetate; In diethyl ether; water; at -78 - 20 ℃;

Reference yield: 50.0%

: 757239-82-0
(2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol

: 757239-84-2
(1R)-1-((2R,3R,4R)-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-tetrahydro-3-phenyl-2H-pyran-4-yl)-1,3-propanediol

Guidance literature:: (2R,3R,4R,αR)-α-(2-propenyl)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}tetrahydro-3-phenyl-2H-pyran-4-methanol; With oxygen; ozone; In methanol; dichloromethane; at -78 ℃; for 0.25 - 0.333333h;

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 ℃; for 0.5h;