tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

Base Information

Chemical Name:tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate
CAS No.:1338473-76-9
Molecular Formula:C₂₂H₁₉Cl₃F₄N₂O₃
Molecular Weight:541.757
Hs Code.:

Synonyms:tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

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Chemical Property of tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

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Technology Process of tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

There total 6 articles about tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 864736-87-8
1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 1338473-75-8
tert-butyl{2-fluoro-5-[(E/Z)-(hydroxyimino)methyl]-benzyl}-carbamate

: 1338473-76-9
tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

Guidance literature:: tert-butyl{2-fluoro-5-[(E/Z)-(hydroxyimino)methyl]-benzyl}-carbamate; With N-chloro-succinimide; In N,N-dimethyl-formamide; for 14.8333h; Inert atmosphere;

1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 862248-93-9
(3,4,5-trichlorophenyl)boronic acid

: 1338473-76-9
tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 14.83 h / Inert atmosphere

2.2: 24 h / 20 °C

With N-chloro-succinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1338473-76-9
tert-butyl {5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / -78 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 4 h / 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 14.83 h / Inert atmosphere

4.2: 24 h / 20 °C

With N-chloro-succinimide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; triethylamine; In tetrahydrofuran; hexanes; ethanol; dichloromethane; N,N-dimethyl-formamide;