5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

Base Information

Chemical Name:5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione
CAS No.:191591-71-6
Molecular Formula:C₁₂H₁₅ClN₂O₂
Molecular Weight:254.716
Hs Code.:

Synonyms:5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

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Chemical Property of 5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

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Technology Process of 5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

There total 1 articles about 5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36929-61-0
1-methyl-pyrrole-3-carboxylic acid

: 191591-71-6
5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine; Et₃N / CH₂Cl₂ / 5 h / 20 °C

2: 2 N aq. NaOH / tetrahydrofuran / 0.5 h / 20 °C

3: 8.4 percent / P₂O₅; CH₃SO₃H / 0.5 h / 90 °C

With dmap; sodium hydroxide; methanesulfonic acid; phosphorus pentoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Acylation / 2: Hydrolysis / 3: Cyclization;
DOI:10.1248/cpb.48.623

Reference yield: 93.0%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 191591-71-6
5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

: 191591-92-1
5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 38h; Heating;
DOI:10.1248/cpb.48.623

Reference yield:

: 191591-71-6
5-(3-chloropropyl)-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4,8-dione

: 5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-8-hydroxy-2-methyl-2,4,5,6,7,8-hexahydropyrrolo[3,4-c]azepine-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / K₂CO₃; NaI / acetonitrile / 38 h / Heating

2: 99 percent / NaBH₄ / ethanol / 17 h / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; sodium iodide; In ethanol; acetonitrile; 1: Alkylation / 2: Reduction;
DOI:10.1248/cpb.48.623