1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

Base Information

Chemical Name:1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol
CAS No.:1394315-60-6
Molecular Formula:C₂₀H₁₉ClF₃NO₃S
Molecular Weight:445.89
Hs Code.:

Synonyms:1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

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Chemical Property of 1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

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Technology Process of 1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

There total 3 articles about 1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 407-12-5
2-(2,2,2-trifluoroethyl)oxirane

: 1394315-39-9
3-(4-chlorobenzyl)-5-(methylsulfonyl)-1H-indole

: 1394315-60-6
1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

Guidance literature:: 3-(4-chlorobenzyl)-5-(methylsulfonyl)-1H-indole; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

2-(2,2,2-trifluoroethyl)oxirane; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

With water; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.040

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1394315-60-6
1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

2.3: Inert atmosphere

With tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2012.06.040

Reference yield:

: 152879-73-7
5-(methylsulfonyl)-1H-indole

: 1394315-60-6
1-(3-(4-chlorobenzyl)-5-(methylsulfonyl)-indol-1-yl)-4,4,4-trifluorobutan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / toluene / 50 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

2.3: Inert atmosphere

With tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2012.06.040