(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

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Chemical Name:(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate
CAS No.:1443739-10-3
Molecular Formula:C₃₀H₃₇N₃O₆
Molecular Weight:535.64
Hs Code.:

Synonyms:(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

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Chemical Property of (3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

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Technology Process of (3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

There total 12 articles about (3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1443739-06-7
(9aR)-benzyl 8-allyl-7-((R)-3-methyl-1-oxoisochroman-6-yl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate

: 1443739-10-3
(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

: 1443739-09-0
(3R,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8(9H,9aH)-dicarboxylate

Guidance literature:: (9aR)-benzyl 8-allyl-7-((R)-3-methyl-1-oxoisochroman-6-yl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In dichloromethane; at 35 ℃; for 4h;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1443739-10-3
(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: D-glucose; glucose dehydrogenase; keto-reductase enzyme P1B2; β-nicotinamide adenine dinucleotide phosphate disodium salt / aq. phosphate buffer; dimethyl sulfoxide / 48 h / 30 °C / pH 8 / Enzymatic reaction

5.1: hydrogenchloride / 1,4-dioxane / 72 h / 20 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 1 h / 100 °C / Microwave irradiation

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

8.1: ethanol / 3 h / 155 °C / Sealed tube; Microwave irradiation

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

9.2: 0.5 h / 0 °C

10.1: thionyl chloride / 1 h / Reflux

10.2: 1 h / 0 - 90 °C

11.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 35 °C

11.2: 20 °C

With glucose dehydrogenase; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; 1,3-dimethylbarbituric acid; β-nicotinamide adenine dinucleotide phosphate disodium salt; D-glucose; keto-reductase enzyme P₁B₂; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; aq. phosphate buffer; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1374575-61-7
4-bromo-N,N-diethyl-2-(2-oxopropyl)benzamide

: 1443739-10-3
(3S,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: D-glucose; glucose dehydrogenase; keto-reductase enzyme P1B2; β-nicotinamide adenine dinucleotide phosphate disodium salt / aq. phosphate buffer; dimethyl sulfoxide / 48 h / 30 °C / pH 8 / Enzymatic reaction

2.1: hydrogenchloride / 1,4-dioxane / 72 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 1 h / 100 °C / Microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: ethanol / 3 h / 155 °C / Sealed tube; Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.2: 0.5 h / 0 °C

7.1: thionyl chloride / 1 h / Reflux

7.2: 1 h / 0 - 90 °C

8.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 35 °C

8.2: 20 °C

With glucose dehydrogenase; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dimethylbarbituric acid; β-nicotinamide adenine dinucleotide phosphate disodium salt; D-glucose; keto-reductase enzyme P₁B₂; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In 1,4-dioxane; aq. phosphate buffer; ethanol; dichloromethane; dimethyl sulfoxide;