4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine

Base Information

• Chemical Name: 4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine
• CAS No.: 1020541-01-8
• Molecular Formula: C₁₃H₉ClF₃N₃O
• Molecular Weight: 315.682
• Mol file: 1020541-01-8.mol

Synonyms:4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine

Chemical Property of 4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine

There total 1 articles about 4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-4-(4-Chloro-phenyl)-1,1,1-trifluoro-4-methoxy-but-3-en-2-one + acetylguanidine (5699-40-1) → 4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine (1020541-01-8)

Guidance literature:

In acetonitrile; at 80 - 85 ℃; for 24h;

DOI:10.1002/jhet.5570450228

Reference yield: 86.0%

4-trifluoromethyl-6-(4-chlorophenyl)-2-acetylaminopyrimidine (1020541-01-8) → 2-amino-4-(4-chlorophenyl)-6-(trifluoromethyl)pyrimidine (883004-97-5)

Guidance literature:

With ferric nitrate; In methanol; at 40 ℃; for 24h;

DOI:10.1002/jhet.5570450228

upstream raw materials:

acetylguanidine

Downstream raw materials:

2-amino-4-(4-chlorophenyl)-6-(trifluoromethyl)pyrimidine