Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

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Chemical Name:Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester
CAS No.:507480-57-1
Molecular Formula:C₆₆H₁₁₀O₁₁SSi₃
Molecular Weight:1195.92
Hs Code.:

Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

Synonyms:Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

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Chemical Property of Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

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Technology Process of Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

There total 6 articles about Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: Tributyl-((E)-(R)-1-methoxymethoxy-oct-2-en-7-ynyl)-stannane

: 507480-56-0
Toluene-4-sulfonic acid (1S,2R,8S)-1-[(3R,4R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-7-oxo-heptyl]-8-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-dodecyl ester

: 507480-57-1
Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

Guidance literature:: With indium(III) bromide; In ethyl acetate; at 20 ℃; for 17h;
DOI:10.1021/jo026433x

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 507480-57-1
Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 24 h / 20 °C

2: H₂ / Pd/C / ethanol / 15.5 h

3: 720 mg / oxalyl chloride; Et₃N; DMSO / CH₂Cl₂ / 1 h / 20 °C

4: 92 percent / InBr₃ / ethyl acetate / 17 h / 20 °C

With pyridine; oxalyl dichloride; indium(III) bromide; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 3: Swern oxidation;
DOI:10.1021/jo026433x

Reference yield:

: 204572-66-7
(4R,5R)-8-Benzyloxy-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-octanal

: 507480-57-1
Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,7S)-7-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethoxy-undecyl]-8-hydroxy-9-methoxymethoxy-hexadec-10-en-15-ynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / InBr₃ / ethyl acetate / 17 h / 20 °C

2: 88 percent / pyridine / 24 h / 20 °C

3: H₂ / Pd/C / ethanol / 15.5 h

4: 720 mg / oxalyl chloride; Et₃N; DMSO / CH₂Cl₂ / 1 h / 20 °C

5: 92 percent / InBr₃ / ethyl acetate / 17 h / 20 °C

With pyridine; oxalyl dichloride; indium(III) bromide; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 4: Swern oxidation;
DOI:10.1021/jo026433x