3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol

Base Information

• Chemical Name: 3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol
• CAS No.: 1062158-90-0
• Molecular Formula: C₂₀H₂₄N₆O₂
• Molecular Weight: 380.45

Synonyms:3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol

Chemical Property of 3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol

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Technology Process of 3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol

There total 1 articles about 3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenol (1062158-87-5) → 3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol (1062158-90-0)

Guidance literature:

With hydrogen; 10 % Pd(OH)2/C; In methanol; for 3h; under 760.051 Torr;

Reference yield:

3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol (1062158-90-0) + Cyclopropanecarboxaldehyde (1489-69-6) → 3-{1-[1-(cyclopropylmethyl)piperidin-4-yl]-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol (1062158-97-7)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol;

Reference yield:

3-(4-morpholin-4-yl-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol (1062158-90-0) + cyclopropanecarboxylic acid chloride (4023-34-1) → 3-{1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol (1062159-08-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h;

upstream raw materials:

3-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenol

Downstream raw materials:

3-{1-[1-(cyclopropylmethyl)piperidin-4-yl]-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol

3-{1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol

3-{4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol

3-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenol

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