tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

Base Information

Chemical Name:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate
CAS No.:1428935-54-9
Molecular Formula:C₃₉H₄₉N₅O₉S
Molecular Weight:770.857
Hs Code.:

tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

Synonyms:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

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Chemical Property of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

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Technology Process of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

There total 13 articles about tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1402390-42-4
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromo-pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

: 1428935-53-8
4,4,5,5-tetramethyl-2-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]-1,3,2-dioxaborolane

: 1428935-54-9
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate; In ethanol; water; toluene; at 75 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1428935-59-4
C₉H₁₂BrN₃Si*C₇H₈O₃S

: 1428935-54-9
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / water; ethyl acetate / 0.5 h

1.2: 0.5 h

1.3: charcoal (Darco G-60); Celite / 2 h

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 16 h / 20 °C

4.1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate / water; ethanol; toluene / 1.5 h / 75 °C / Inert atmosphere

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate; potassium hydrogencarbonate; triethylamine; In ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1225062-32-7
tert-butyl N-tert-butoxycarbonyl-N-[5-bromo-3-((trimethylsilyl)ethyynyl)pyrazin-2-yl]carbamate

: 1428935-54-9
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-[4-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethyl]sulfonylphenyl]pyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 20 °C

3: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate / water; ethanol; toluene / 1.5 h / 75 °C / Inert atmosphere

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; toluene; acetonitrile;