tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate
CAS No.:1427309-31-6
Molecular Formula:C₂₉H₄₅N₃O₅
Molecular Weight:515.693
Hs Code.:

Synonyms:tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

There total 14 articles about tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

: 1427309-24-7
(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1427309-31-6
tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1-benzyl (4-methoxyphenyl)methyl (3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-1,3-dicarboxylate

: 1427309-31-6
tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 38.08 h / 20 °C

2: sodium tris(acetoxy)borohydride; methanol; acetic acid / 38.5 h / 40 °C

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With methanol; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: (3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

: 1427309-31-6
tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; methanol; acetic acid / 38.5 h / 40 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In N,N-dimethyl-formamide;