N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

Base Information

Chemical Name:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide
CAS No.:1295567-58-6
Molecular Formula:C₂₅H₂₃F₂N₃O₅S₂
Molecular Weight:547.604
Hs Code.:

Synonyms:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

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Chemical Property of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

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Technology Process of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

There total 6 articles about N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295567-81-5
C₂₈H₃₁F₂N₃O₅S₂Si

: 1295567-58-6
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

Guidance literature:: C₂₈H₃₁F₂N₃O₅S₂Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295567-58-6
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.2: 20 h / 20 °C / Inert atmosphere

2.3: 3 h / 50 °C

3.1: pyridine / 48 h / 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 3 h / 60 °C / Inert atmosphere; Sealed tube

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 765962-75-2
3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1295567-58-6
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-6-[(4-ethynyl-2-fluorophenyl)amino]-4-fluorophenyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

1.2: 20 h / 20 °C / Inert atmosphere

1.3: 3 h / 50 °C

2.1: pyridine / 48 h / 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 3 h / 60 °C / Inert atmosphere; Sealed tube

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;