2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

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Chemical Name:2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole
CAS No.:1620516-05-3
Molecular Formula:C₁₃H₁₁BrN₄OS
Molecular Weight:351.227
Hs Code.:

Synonyms:2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

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Chemical Property of 2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

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Technology Process of 2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

There total 3 articles about 2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1620516-04-2
5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-amine

: 1620516-05-3
2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

Guidance literature:: With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 89942-34-7
2-methoxy-4-iodobenzoic acid

: 1620516-05-3
2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / water / 1 h / 0 - 78 °C / Cooling with ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

3: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; sodium carbonate; copper(ll) bromide; trichlorophosphate; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1388044-60-7
5-(4-iodo-2-methoxyphenyl)-1,3,4-thiadiazol-2-amine

: 1620516-05-3
2-bromo-5-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; sodium carbonate; copper(ll) bromide; In 1,4-dioxane; water; acetonitrile;