2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Base Information

Chemical Name:2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one
CAS No.:922172-18-7
Molecular Formula:C₂₆H₃₈O₆S
Molecular Weight:478.65
Hs Code.:

Synonyms:2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

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Chemical Property of 2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

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Technology Process of 2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

There total 10 articles about 2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 922172-17-6
2-benzenesulfonyl-2-methyldecanal

: 56070-87-2
2-methoxy-3,5,6-trimethyl-4H-pyran-4-one

: 922172-18-7
2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: 2-methoxy-3,5,6-trimethyl-4H-pyran-4-one; With lithium diisopropyl amide; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

2-benzenesulfonyl-2-methyldecanal; In tetrahydrofuran; pentane; at -78 ℃; for 2h;
DOI:10.1021/ol0626140

Reference yield:

: 922172-21-2
6-(2-hydroxy-1-methyl-propyl)-2,2,5-trimethyl-[1,3]dioxin-4-one

: 922172-18-7
2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4.00 g / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

2.1: 83 percent / sodium methoxide / methanol / 0 °C

3.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

4.1: LDA / tetrahydrofuran; pentane / 1 h / -78 °C

4.2: 74 percent / pentane; tetrahydrofuran / 2 h / -78 °C

With oxalyl dichloride; sodium methylate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; pentane; 1.1: Swern oxidation / 4.2: aldol reaction;
DOI:10.1021/ol0626140

Reference yield:

: 922172-14-3
6-(1-methyl-2-oxopropyl)-2,2,5-trimethyl-4H-1,3-dioxin-4-one

: 922172-18-7
2-(3-benzenesulfonyl-2-hydroxy-3-methyldecyl)-6-methoxy-3,5-dimethyl-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 83 percent / sodium methoxide / methanol / 0 °C

2.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

3.1: LDA / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 74 percent / pentane; tetrahydrofuran / 2 h / -78 °C

With sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; pentane; 3.2: aldol reaction;
DOI:10.1021/ol0626140