(3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
• CAS No.: 1169769-92-9
• Molecular Formula: C₂₈H₂₈N₂O₅
• Molecular Weight: 472.541

Synonyms:(3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Chemical Property of (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

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Technology Process of (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

There total 5 articles about (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate (862907-10-6) + (2-nitroethenyl)benzene (102-96-5) → (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (1169769-92-9)

Guidance literature:

With C₄₆H₅₁N₃O₂; In diethyl ether; at -40 - 20 ℃; for 41h; Solvent; Temperature; Reagent/catalyst; Time; enantioselective reaction;

DOI:10.1039/c4cc01817f

Reference yield:

tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate (862907-10-6) + (2-nitroethenyl)benzene (102-96-5) → (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (1169769-92-9) + (3S)-tert-butyl 3-benzyl-3-[(1R)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate (1333342-48-5) + tert-butyl 3-benzyl-3-[2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

Guidance literature:

With quinine; In chloroform; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate (862907-10-6) + (2-nitroethenyl)benzene (102-96-5) → (3R)-3-benzyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (1169769-92-9) + 3-benzyl-3-[2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:

With C₃₈H₂₆Mn₂N₂O₈; In tetrahydrofuran; ethyl acetate; at 20 - 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja903566u

upstream raw materials:

tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate

(2-nitroethenyl)benzene

nitrostyrene

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