methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

Base Information

Chemical Name:methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate
CAS No.:349104-92-3
Molecular Formula:C₂₀H₁₄ClN₃O₅
Molecular Weight:411.801
Hs Code.:

Synonyms:methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

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Chemical Property of methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

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Technology Process of methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

There total 8 articles about methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 349105-58-4
C₂₉H₃₁ClN₄O₇

: 349104-92-3
methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

Guidance literature:: With methanesulfonic acid; In tetrahydrofuran;
DOI:10.1021/jm060212s

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 349104-92-3
methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 47 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 11 h / Heating

2.1: 60 percent / aq. NaOH / H₂O / 1 h / 60 °C

3.1: 94.3 percent / DCC / tetrahydrofuran / 15 h / 20 °C

4.1: 64 percent / aq. KOH / H₂O / 3 h / 60 °C

5.1: CMC / tetrahydrofuran

5.2: 100 percent / tetrahydrofuran

6.1: 40 percent / methanesulfonic acid / tetrahydrofuran

With potassium hydroxide; sodium hydroxide; methanesulfonic acid; potassium tert-butylate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm060212s

Reference yield:

: 170143-35-8,170143-39-2
3-carbomethoxy-7-chloro-4-hydroxyquinoline-2-carboxylic acid

: 349104-92-3
methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94.3 percent / DCC / tetrahydrofuran / 15 h / 20 °C

2.1: 64 percent / aq. KOH / H₂O / 3 h / 60 °C

3.1: CMC / tetrahydrofuran

3.2: 100 percent / tetrahydrofuran

4.1: 40 percent / methanesulfonic acid / tetrahydrofuran

With potassium hydroxide; methanesulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; water;
DOI:10.1021/jm060212s