N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

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Chemical Name:N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide
CAS No.:1192573-98-0
Molecular Formula:C₂₄H₂₄N₆O₃
Molecular Weight:444.493
Hs Code.:

Synonyms:N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

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Chemical Property of N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

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Technology Process of N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

There total 4 articles about N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1192573-89-9
2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-amine

: 1759-53-1
cyclopropanecarboxylic acid

: 1192573-98-0
N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

Guidance literature:: With triethylamine; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

: 6919-61-5
N-methoxy-N-methylbenzamide

: 1192573-98-0
N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: pyridine; hydroxylamine hydrochloride / 75 h / 20 - 50 °C

3.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 101 h / 20 °C

4.1: triethylamine / 1,4-dioxane / 24 h / 20 °C

With pyridine; ethylmagnesium bromide; hydroxylamine hydrochloride; caesium carbonate; triethylamine; potassium iodide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1192575-99-7
N-hydroxy-1-(1-methyl-1H-imidazol-5-yl)-1-phenylmethanimine

: 1192573-98-0
N-(cyclopropylcarbonyl)-N-{2-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 101 h / 20 °C

2: triethylamine / 1,4-dioxane / 24 h / 20 °C

With caesium carbonate; triethylamine; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;